BENCH to BEDSIDE

Explore the Cores: Talking Transformational Technology, Throughput Sequencing & Trees with Teodora Orendovici, PhD

Today’s high throughput sequencing techniques empower researchers to sequence a genome, epigenome, and transcriptome faster than ever before. At Children’s Hospital of Philadelphia Research Institute, Teodora Orendovici, PhD, Technical Director of the High Throughput Sequencing Core (HTS), is a passionate expert and leader devoted to ensuring all investigators, regardless of their research interests and goals, have access to the most advanced sequencing technologies. Accessibility and equity is critical, says Dr. Orendovici, if we are to develop a world where personalized medicine becomes possible for all patients. 

Explore the Cores: Illuminating Discoveries With CHOP’s Flow Cytometry Core

In the second part of our Explore the Cores series, Florin Tuluc, MD, PhD, Director of the Flow Cytometry Core Laboratory at CHOP Research Institute, sits down with host Susan Furth, MD, PhD, Chief Scientific Officer, to talk about what makes the Flow Lab a unique and valuable resource for the CHOP scientific community. Spoiler: It’s one-part state-of-the-art technology and two parts a team of incredible individuals with a passion for pediatric health.

Explore the Cores: CHOP Biorepository Houses Specimens & Hope for Pediatric Breakthroughs

Have you ever wondered how, and where, biospecimen samples go after a patient gives consent for its use in research? The latest guest of our Bench to Bedside podcast, David Stokes, PhD, is the Technical Director of the Biorepository Resource Center at CHOP, a core facility that serves all of CHOP’s biobanking needs. With the unique capacity to store 3 million samples and the highly advanced infrastructure to keep the specimens organized, preserved, and accessible to the research community, the BioRC also houses immense hope for breakthroughs in children’s health. Listen in as Dr. Stokes shares how the BioRC has evolved over a decade to become one of CHOP’s most unique and valuable research resources.

New Frontiers: Precision Medicine a ‘Unique Signature’ for Pediatric Cancer Patients

Precision medicine, also known as personalized medicine, has revolutionized how physicians and scientists treat and study disease. According to Theodore Laetsch, MD, an oncologist at Children’s Hospital of Philadelphia, this ability to track and tailor individual patients’ unique genetic signatures has the most transformative potential in pediatric cancer. In this episode of Bench to Bedside, Dr. Laetsch shares how his new Frontier Program, the Center for Precision Medicine for High-risk Pediatric Cancer, harnesses advanced technologies and a growing multi omics database to optimize outcomes for childhood cancer patients.

New Frontiers: Talking Heart-to-Heart About Pediatric Heart Failure

From pathology to prognosis, heart failure in children appears vastly different than it does in adults. How we study, approach, and ultimately treat the disease should too, according to Joseph Rossano, MD, chief of the Division of Cardiology at CHOP. As director of the Advanced Cardiac Therapies for Heart Failure Patients Frontier Program, Dr. Rossano aims to bring cutting-edge scientific discoveries from the bench to the bedside with this in mind. 

New Frontiers: At the Forefront of Hemophilia Treatment With CHOP

With a stroll down the hallway at Children’s Hospital of Philadelphia, you run into a tremendous knowledge base and expertise to help answer challenging scientific questions in pediatrics. Lindsey George, MD, PhD, director of the Novel Therapeutics for Bleeding Disorders Frontier Program, shares how this combined clinical experience in gene therapy for hemophilia and in other related bleeding disorders leads toward innovative approaches.

New Frontiers: CHOP Neonatologists Develop the Delivery Room of the Future

Since establishing the first surgical intensive care unit (ICU) for newborns and infants in 1962, Children’s Hospital of Philadelphia has been at the forefront of transforming care for its tiniest patients. The Delivery Room of the Future Frontier Program, directed by neonatologist Elizabeth Foglia, MD, aims to provide every infant a chance at the healthiest outcomes and quality of life. 

100 Years of Research: Driven to Prevent Injury in Children

“Be bold. Solve important problems,” shares Bench to Bedside guest, Flaura Winston, MD, PhD, founder and co-scientific director of the Center for Injury Research and Prevention. Hear how this Center of Emphasis takes a research action to impact approach when it comes to preventing injury in children. 

100 Years of Research: Bringing ‘Amazingly Creative Ideas’ to Discover New Gene and Cell Therapies

Dr. Beverly Davidson and her multidisciplinary team at the Raymond G. Perelman Center for Cellular and Molecular Therapeutics are working on “aha moments,” both big and small, to improve gene and cell therapies in search of cures for debilitating disorders.

Center for Applied Genomics: Translating Basic Research Findings Into Medical Innovations

Join the conversation with Hakon Hakonarson, MD, PhD, founding director of the Center for Applied Genomics, where scientists develop new and better ways to diagnose and treat children affected by rare and complex medical disorders.